Talin



Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3. The images at the left and at the right correspond to one representative Talin, i.e. the crystal structure of mouse Talin rod (2x0c).

Talin subdomains
2x0c, 2kbb, 3dyj, 1sj7, 1sj8 – mTal rod – mouse

2kma – mTal F0F1 – NMR

2kc1 - mTal F0 – NMR

2kc2 - mTal F1 – NMR

2hrj - cTal F2 – NMR

1mix – cTal F2F3

2kgx – mTal F3+mTal fragment – NMR

3ivf – mTal FERM domain

Integrin binding sites
2jsw, 2qdq – mTal IBS – NMR

3g9w – mTal F2F3+integrin tail

1miz, 1mk7, 1mk9 - hTal+integrin tail

2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR

3fyq – Tal rod IBS2 – Drosophila melanogaster

Vinculin binding sites
2kvp, 2b0h – mTal VBS3 – NMR

1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken

1u6h - cTal VBS2+ vinculin head

1t01 - cTal VBS1+ vinculin head

1syq - hTal VBS1+ vinculin head – human

1rkc - hTal VBS3+ vinculin head

1u89 - mTal VBS2 – NMR

PIP kinase binding sites
1y19 - mTal F2F3+ PIP kinase C-terminal

2g35 - mTal F3+PIP kinase peptide – NMR

Layilin binding sites
2k00 - cTal F3+layilin fragment – NMR